by Giana Jarrah, Biomedical Engineer & Vaginal Health Expert
If there’s one thing I wish more women were taught early on, it’s this: your hormones are not your enemy—they’re your body’s language. And when we don’t listen, we miss powerful clues about our health.
At With Meraki Co., we created With Harmony because hormonal imbalance doesn’t always scream—it whispers. Through mood swings, painful periods, adult acne, vaginal dryness, and yes, even recurrent infections. But behind these symptoms is often a deeper story about the gut-brain-vagina-hormone connection. Let’s break down what that actually means—and how to start balancing from within.
The Real Root of Hormonal Chaos
It’s easy to think of hormones as separate entities, but they operate in a deeply connected ecosystem. Estrogen, progesterone, cortisol, insulin, thyroid hormones—they all communicate, all the time. What many overlook is the central role of the gut microbiome in regulating this entire system.
The Estrobolome: Your Hidden Hormone Modulator
The estrobolome is a unique collection of gut bacteria involved in metabolizing estrogen. When gut imbalance (or dysbiosis) occurs—often from antibiotics, a pro-inflammatory diet, or chronic stress—the activity of an enzyme called beta-glucuronidase increases. This causes estrogen that should be excreted to recirculate, contributing to heavy periods, breast tenderness, and estrogen-dominant symptoms.
With Harmony includes targeted probiotic strains and prebiotics that help regulate this enzyme, ensuring estrogen is processed and cleared efficiently rather than building up in the body.
Gut-Brain-Ovary Axis: Why Stress Isn’t Just Mental
Most people don’t realize that the ovaries are rich in cortisol receptors. Chronic stress sends a message to your body: this isn’t a safe time to prioritize reproduction. That signal alone can downregulate estrogen and progesterone production.
The kicker? Cortisol is also regulated through your gut. Over 60% of cortisol clearance happens via the microbiome. A well-balanced gut helps reduce the circulating stress load and protects your endocrine system from burnout.
Specific strains in With Harmony, such as Lactobacillus rhamnosus GG, have been clinically shown to reduce cortisol, support mood stability, and promote production of GABA—a calming neurotransmitter linked to PMS and PMDD relief.
Vaginal Symptoms as Hormonal Red Flags
Recurring BV, yeast infections, or UTIs aren’t just hygiene concerns. They’re often signs of low estrogen or low progesterone. Estrogen specifically helps nurture Lactobacillus crispatus, the dominant strain in a healthy vaginal microbiome. It helps maintain a low pH and protective biofilm against pathogens.
When hormone levels drop—whether due to perimenopause, postpartum, or stress—this defense weakens, and infections can recur.
With Harmony was formulated with strains that have the ability to migrate from the gut to the vaginal tract, re-establishing Lactobacillus dominance and helping reduce the recurrence of hormonally linked infections.
Hormone Intelligence > Hormone Hacks
The goal of With Harmony isn’t a quick fix. It’s a long-term recalibration of your hormonal rhythm, based on clinical data and microbiome science.
Here’s what makes it different:
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Microbiome modulation to support estrogen detoxification via the estrobolome
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Cortisol regulation through stress-resilient probiotic strains
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Vaginal ecosystem restoration with proven Lactobacillus strains
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Improved cycle tracking from ovulation to period quality as the microbiome and hormone patterns stabilize
Many women report more regular cycles, fewer PMS symptoms, and greater emotional resilience after just one to three months of use.
A Final Thought from a Biomedical Engineer
In engineering, every system is only as strong as its feedback loops. Hormones are no different. When the gut is inflamed, stress is chronic, and the vaginal microbiome is disrupted, those feedback loops misfire.
But with the right microbial allies, nutrients, and endocrine support, the body knows how to regulate itself. That’s the power of giving your system the raw materials it needs to heal.
With Harmony was created for the woman who’s ready to understand her cycle, regulate her mood, and stop fighting her body. It’s for those who want to move forward with hormone confidence—not confusion.
Ready to reconnect with your hormonal rhythm?
Start your journey with With Harmony